流行性出血热是布尼亚病毒科汉坦病毒属引发、由野鼠或家鼠传播的急性传染病,病死率约为5％。我国26个省、市、自治区有该病流行,发病人数居世界首位,每年约5万～8万例,死亡数千例。由于缺乏特效治疗药物,且控制和消灭鼠类的工作难度很大,因此研究一种特异性疫苗是预防该病的重要措施。中国药品生物制品检定所等单位在承担的《流行性出血热疫苗研制》课题研究中首次发现,沙鼠肾细胞和地鼠肾细胞对出血热病毒敏感,并将筛选的三株抗原性好、免疫原性高的病毒株,分别适用于沙鼠肾细胞、地鼠肾细胞和鼠脑组织 Epidemic haemorrhagic fever is an acute infectious disease caused by Hantavirus of the Bunyavirus family and transmitted by wild or domestic mice, with a case fatality rate of approximately 5%. In 26 provinces, cities and autonomous regions in China, the disease prevalence ranks the first in the world with about 50,000 to 80,000 cases a year and thousands of deaths. Due to the lack of specific treatment drugs and the difficulty of controlling and eradicating mice, the study of a specific vaccine is an important measure to prevent this disease. China Pharmaceutical and Biological Products Inspection and other units in commitment to “epidemic hemorrhagic fever vaccine research” research for the first time found that gerbil and hamster kidney cell hemorrhagic fever virus sensitivity, and screening of the three antigenicity is good, Immunogenicity of the virus strains were applied to gerbular kidney cells, mouse kidney cells and rat brain tissue