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目的 探讨转化生长因子 β(TGF- β)在重症肌无力 (MG)免疫病理机理中的作用。方法 应用体外细胞培养和 EL ISA方法检测 MG患者外周血单个核细胞经乙酰胆碱受体 (Ach R)刺激后产生 TGF-β的水平。结果 MG患者外周血单个核细胞 TGF-β水平高于正常对照组 ,且 TGF-β水平与病程有关。结论 MG患者自身免疫功能异常 ,TGF- β参与了 MG的免疫病理过程
Objective To investigate the role of transforming growth factor-β (TGF-β) in the pathogenesis of myasthenia gravis (MG). Methods The levels of TGF-β in peripheral blood mononuclear cells stimulated by acetylcholine receptor (Ach R) in MG patients were detected by in vitro cell culture and ELISA. Results The level of TGF-β in peripheral blood mononuclear cells of patients with MG was higher than that of normal control group, and the level of TGF-β was related to the course of disease. Conclusion MG patients with autoimmune dysfunction, TGF- β involved in the immune pathology of MG