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目的 观察羟基喜树硷 (HCPT) ,足乙叉甙 (VP 16 ) ,甲酰四氢叶酸钙 (LV)加 5一氟脲嘧啶 (5 Fu)组成HELF联合化疗方案对晚期胃癌的疗效。方法自 1993年 4月至 1997年 2月 ,用HELF方案治疗 52例晚期胃癌 ,具体用药 :HCPT8mg m2 divd1～ 5;VP - 16 6 0mg m2 divd1～ 5;LV10 0mg m2 divd1～ 5;5-FU6 0 0mg m2 divd1～ 5。结果 52例病人中达完全缓解的有 4例 (CR7 6 9% ) ;部分缓解 2 5例 (PR4 8 0 7% ) ;总有效率 (CR +PR)是 55 76 % ,其有效率高于对照组ELF方案 4 1 16 % (P <0 0 5)。中位生存期 10个月也优于对照组 7 5个月 (P <0 0 5)。毒副反应轻
Objective To observe the effects of HCPT, VP 16, LV and 5 Fu combined with HELF plus chemotherapy on advanced gastric cancer. Methods From April 1993 to February 1997, 52 patients with advanced gastric cancer were treated with HELF regimen. The specific drugs were: HCPT 8mg m2 divd1-5; VP16600mg m2 divd1-5; LV10 0mg m2 divd1-5; 5-FU6 0 0mg m2 divd1 ~ 5. Results The complete remission was achieved in 52 patients (CR7 6 9%), partial remission was 25 (PR4 80 7%), and the total effective rate (CR + PR) was 55 76% The control group ELF regimen 4 1 16% (P <0 0 5). The median survival time was also 10 months better than the control group 75 months (P <0 05). Toxic side effects