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将护骨胶囊用于80例自然绝经或人工绝经10年内的妇女,通过前瞻性观察用药前后骨矿物质含量(Bone Mineral Content,BMC)、骨代谢尿钙/肌酐(Ca/Cr)、尿羟脯氨酸/肌酐(HOP/Cr)值的变化,以尼尔雌醇为对照,探讨其对绝经后妇女骨量及骨代谢的作用。结果显示用药后尿 Ca/Cr 及尿 HOP/Cr 值明显低于用药前(P<0.05),BMC 测定用药前后均值比较无显著差异(P>0.05),但用药后有上升趋势,结果同尼尔雌醇。说明护骨胶囊有调节骨代谢向正平衡发展作用,有抗骨质丢失作用。
The Gugu capsule was applied to 80 women with natural or artificial menopause for 10 years. Prospective observation of Bone Mineral Content (BMC), bone metabolism of urinary calcium/creatinine (Ca/Cr), urinary hydroxyl Changes in valine/creatinine (HOP/Cr) values were compared with nylestriol as a control to investigate its effect on bone mass and bone metabolism in postmenopausal women. The results showed that the urinary Ca/Cr and urinary HOP/Cr values were significantly lower than those before treatment (P<0.05). There was no significant difference in the mean value before and after administration of BMC (P>0.05), but there was an upward trend after treatment. Estradiol. It is indicated that the protective bone capsule regulates the development of bone metabolism towards positive balance and has anti-bone loss effect.