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报道不同剂量浓缩铀UO_2F_2内污染后,对脾脏、胸腺和骨髓免疫细胞DNA合成的免疫毒理效应。结果发现,当浓缩铀摄入量为10～500μg/kg体重时,脾T、B淋巴细胞和胸腺淋巴细胞~3H-TdR掺入降低(P<0.05或0.01),呈现对DNA合成的抑制效应,但当浓缩铀摄入量降至0.1μg/kg体重时,脾PHA反应性T淋巴细胞~3H-TdR掺入高于对照组(P<0.05),对DNA合成呈现出明显的刺激效应。不同免疫细胞的辐射敏感性越高,诱发其刺激效应的放射性核素的剂量越低。应用数学方法对不同免疫细胞的剂量效应数据回归出相应的方程,呈直线平方模型。浓缩铀内污染14天后,各免疫细胞~3H-TdR掺入未见恢复正常。
The toxicological effects of different doses of uranium enriched UO_2F_2 on the DNA synthesis of spleen, thymus, and bone marrow immune cells were reported. As a result, when the enriched uranium intake was 10 to 500 μg/kg body weight, the incorporation of 3H-TdR in spleen T and B lymphocytes and thymocytes decreased (P<0.05 or 0.01), and the inhibition of DNA synthesis was exhibited. However, when the intake of enriched uranium decreased to 0.1 μg/kg body weight, the incorporation of ~3H-TdR in the spleen PHA-reactive T lymphocytes was higher than that in the control group (P<0.05), showing a significant stimulating effect on DNA synthesis. The higher the radiation sensitivity of different immune cells, the lower the dose of radionuclide that induces its stimulatory effect. The mathematics method was used to regress the dose-response data of different immune cells to the corresponding equation, which was a linear square model. After 14 days of enriched uranium contamination, ~3H-TdR incorporation did not return to normal in all immune cells.