自1957年Cope等报告甲状旁腺功能亢进症合并胰腺炎以来,欧美已有许多报告,并认为甲状旁腺功能亢进症是胰腺炎的一个发病因素。甲状旁腺功能亢进症并发胰腺炎的发生率各作者报告不一,大致为10～15%。两病合并发生时,先发生甲状旁腺功能亢进症还是胰腺炎?目前多数认为甲状旁腺功能亢进症先发生。甲状旁腺功能亢进症并发胰腺炎的机制目前尚有许多不够明了,但大致认为有以下三点:①甲状旁腺功能亢进时由于血钙持续增高,胰液中排出的钙浓度也增高,碱性的胰液促使胰管内结石形成,从而导致胰管闭塞诱发胰腺炎的发生。但多数学者并未发现结石,因此不同意这种见解。②由于甲状旁腺肿瘤分泌过多的甲状旁腺激素成为胰腺炎发病的直接原因。给动物过多的甲状旁腺激素能引起胰腺组织的损伤,最后发生钙化。另外在重症甲状旁腺功能亢进危象时, Cope and other reports from 1957 hyperparathyroidism associated with pancreatitis, Europe and the United States have been many reports, and that hyperparathyroidism is a pancreatitis incidence. The incidence of hyperparathyroidism complicated with pancreatitis reported by different authors varies, roughly 10 to 15%. When the combination of the two diseases occurs, whether hyperparathyroidism or pancreatitis occurs first? Currently, most people think that hyperparathyroidism occurs first. Hyperparathyroidism complicated with pancreatitis mechanism is still not clear enough, but generally considered to have the following three points: ① hyperparathyroidism due to continued increase in serum calcium, pancreatic juice discharged in the calcium concentration is also increased, alkaline Of pancreatic juice to promote the formation of pancreatic duct stones, resulting in the occurrence of pancreatic duct-induced pancreatitis. However, most scholars did not find stones, so do not agree with this view. ② parathyroid tumors due to excessive secretion of parathyroid hormone as the direct cause of pancreatitis. To animals too much parathyroid hormone can cause pancreatic tissue damage, the final occurrence of calcification. In addition, in severe hyperparathyroidism crisis,