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目的:探讨子痫前期(PE)患者的血清中性粒细胞白明胶酶转运蛋白水平(NGAL)与PE严重程度的关系。方法:选取2011年9月至2013年4月在我院产科住院并分娩的单胎正常妊娠孕妇61例、轻度PE患者33例及重度PE患者24例。比较3组患者的孕前BMI、及新生儿出生体重,测定患者的24h尿蛋白和肌酐水平,应用酶联免疫吸附法(ELISA)测定血清NGAL水平,分析PE患者血清NGAL水平与24h尿蛋白和肌酐的相关性。结果:重度、轻度PE患者的血清NGAL水平显著高于正常妊娠孕妇[(83.8±14.9)ng/ml、(52.8±20.4)ng/ml vs(16.4±8.8)ng/ml,P<0.001],重度PE患者显著高于轻度PE患者(P<0.001)。PE患者的血清NGAL水平与24h尿蛋白(r=0.457,P<0.001)、肌酐(r=0.497,P<0.001)呈正相关性。结论:血清NGAL水平在PE患者中升高,且NGAL可能和疾病的严重程度有关。
Objective: To investigate the relationship between serum neutrophil gelatinase transporter (NGAL) and the severity of PE in patients with preeclampsia (PE). Methods: From September 2011 to April 2013, 61 pregnant women with singletonic normal pregnancy who were hospitalized and delivered in obstetrics and gynecology department of our hospital, 33 patients with mild PE and 24 patients with severe PE were enrolled. Pre-pregnancy BMI and birth weight of newborns were compared between the three groups, 24h urinary protein and creatinine were measured. Serum NGAL levels were measured by enzyme-linked immunosorbent assay (ELISA), serum NGAL levels and serum levels of urinary protein and creatinine Relevance. Results: Serum NGAL levels in patients with severe and mild PE were significantly higher than those in normal pregnant women (83.8 ± 14.9 ng / ml, 52.8 ± 20.4 ng / ml vs 16.4 ± 8.8 ng / ml, P <0.001) , Severe PE patients were significantly higher than mild PE patients (P <0.001). The level of serum NGAL in PE patients was positively correlated with 24h urinary protein (r = 0.457, P <0.001) and creatinine (r = 0.497, P <0.001). Conclusion: Serum NGAL levels are elevated in patients with PE, and NGAL may be related to the severity of the disease.