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采用ＰＣＲ扩增方法鉴定１３７例急性脑血管病（脑出血７１例，脑血栓形成５２例，蛛网膜下腔出血１４例）病人和１８６例正常对照的血管紧张素Ⅰ转换酶（ＡＣＥ）基因多态性，以观察急性脑血管病的发病与ＡＣＥ基因多态性之间的关系。结果发现：脑出血病人ＡＣＥ插入／插入（ⅠⅠ）纯合型频率明显高于对照组（０．５０７ＶＳ０．３６），而缺失／缺失（ＤＤ）纯合型频率则明显低于对照组（０．０７ＶＳ０．１７２）（Ｐ＝０．０３５４）；脑血栓形成和蛛网膜下腔出血病人ＡＣＥ基因多态频率与对照组差别不大（Ｐ＞０．０５）。提示ＡＣＥ基因ⅠⅠ纯合型可能为脑出血患者发病的易感因子。
A total of 137 patients with acute cerebrovascular disease (71 with cerebral hemorrhage, 52 with cerebral thrombosis, 14 with subarachnoid hemorrhage) and 186 normal control subjects were enrolled in this study. To observe the relationship between the incidence of acute cerebrovascular disease and ACE gene polymorphism. The results showed that the frequency of homozygous ACE insertion / insertion (ⅠⅠ) in patients with ICH was significantly higher than that in control group (0.507VS0.36), while the frequency of deletion / deletion (DD) homozygotes was significantly lower than that of control group (0. 07VS0.172) (P = 0.0354). The frequency of ACE gene polymorphism in patients with cerebral thrombosis and subarachnoid hemorrhage was not significantly different from that in control group (P> 0.05). Tip Ⅰ gene homozygosity ACE gene may be a predisposing factor in patients with cerebral hemorrhage.