临床观察到血管紧张素转化酶抑制剂(ACE-Ⅰ)有引起咳嗽的副作用,有人估计其发生率约为3%～19%。ACE-Ⅰ引起咳嗽的病人有无气道高反应性尚有不同看法。临床上,哮喘和高血压病可能合并存在,ACE-Ⅰ的应用是否引起哮喘加重有一定的临床意义。作者为了解ACE-Ⅰ对已有气道高反应性的哮喘病人的气道反应性(PD20)和症状的影响,而进行了如下实验。 Clinically observed angiotensin converting enzyme inhibitors (ACE-Ⅰ) have a side effect of cough, it was estimated that the incidence of about 3% to 19%. There are different opinions on whether ACE-I causes cough in patients with or without airway hyperresponsiveness. Clinically, asthma and hypertension may be combined, ACE-Ⅰ whether the increase in asthma caused by some clinical significance. The authors performed the following experiments to understand the effect of ACE-I on airway responsiveness (PD20) and symptoms in asthmatics who already have airway hyperresponsiveness.