论文部分内容阅读
目的评价补气活血利水方药联合自体腹水超滤浓缩回输治疗肝硬化顽固性腹水的临床疗效。方法将90例乙肝肝硬化合并顽固性腹水患者随机分为观察组与对照组,每组45例,均接受常规治疗和腹水浓缩回输治疗,观察组患者加用补气活血利水方药。结果观察组和对照组的总有效率分别为88.9%和64.4%(P<0.05)。治疗后,观察组较对照组的丙氨酸氨基转移酶[(44.40±13.10)U/L vs.(56.90±15.50)U/L]、白蛋白[(33.04±3.13)g/L vs.(30.94±3.52)g/L]、总胆红素[(39.04±8.13)μmol/L vs.(52.94±9.52)μmol/L]、直接胆红素[(16.04±4.13)μmol/L vs.(19.94±5.52)μmol/L]、胆碱酯酶[(3 043.55±141.23)mmol/L vs.(2 894.42±169.52)mmol/L]明显改善,差异有统计学意义(P<0.05);肾功能的差异无统计学意义(P>0.05)。组内比较,治疗后各项指标均明显好于治疗前(P<0.05)。发热、肝性脑病、血压下降等不良反应发生率也无明显差异(P>0.05)。结论补气活血利水方联合腹水浓缩回输治疗可以明显提高肝硬化顽固性腹水的临床疗效。
Objective To evaluate the clinical effects of Buqi Huoxue Recipe combined with ultrafiltration of ascites by autologous sequestration in the treatment of refractory cirrhosis and ascites. Methods Ninety patients with hepatitis B cirrhosis and refractory ascites were randomly divided into observation group and control group, with 45 cases in each group. Both patients received conventional therapy and concentrated ascites infusion therapy. Patients in observation group were treated with Buqi Huoxue Recipe. Results The total effective rate of the observation group and the control group were 88.9% and 64.4% (P <0.05). After treatment, the levels of alanine aminotransferase ([44.40 ± 13.10 U / L vs. (56.90 ± 15.50) U / L], albumin [(33.04 ± 3.13) g / L vs. 30.94 ± 3.52 g / L], total bilirubin [(39.04 ± 8.13) μmol / L vs. (52.94 ± 9.52) μmol / L), direct bilirubin (16.04 ± 4.13 μmol / L vs. 19.94 ± 5.52 μmol / L] and cholinesterase [(3 043.55 ± 141.23) mmol / L vs. (2 894.42 ± 169.52) mmol / L], the difference was statistically significant There was no significant difference in function (P> 0.05). After treatment, the indexes in all groups were significantly better than those before treatment (P <0.05). Fever, hepatic encephalopathy, blood pressure and other adverse reactions no significant difference (P> 0.05). Conclusion Buqi Huoxue Recipe combined with transfusion of ascitic fluid can significantly improve the clinical efficacy of refractory cirrhosis and ascites.