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探讨持续心房颤动(AF)对左右房容积及左房功能的影响及其时间进程。运用起搏方法建立AF模型,在AF前和AF后的第1,2,4,8周对左右房容积、左房射血分数(EF)、左房射血力(LAEF)、A峰、E峰及E/A比值进行测量。结果:AF后1,2,4,8周左右房容积逐渐增加、心室舒张末左房容积(LAEDV)在起搏后1周有显著增加(P<0.05);心室收缩末左房容积(LAESV)、心室收缩末右房容积(RAESV)及心室舒张末右房容积(RAEDV)在AF4周时显著增加(P<0.05)。随着AF持续,左房EF值、A峰值及LAEF逐渐降低,左房EF在AF1周后显著降低(P<0.05);A峰值及LAEF在AF2周后显著降低(P<0.05);E/A值逐渐增高,AF2周后显著增高(P<0.05);E峰值无明显变化。结论:持续AF可引起左右房增大,左房功能障碍。
To investigate the effect of persistent atrial fibrillation (AF) on left and right atrial volume and left atrial function and its time course. The AF model was established by pacing method. The left and right atrial ejection fraction (EF), left atrial ejection force (LAEF), A peak, E-peak and E / A ratio measurements. Results: After 1, 2, 4 and 8 weeks AF, the volume of atrial appendages increased gradually. The left ventricular end diastolic volume (LAEDV) increased significantly 1 week after pacing (P <0.05) ), RAESV and RAEDV significantly increased at 4 weeks AF (P <0.05). With the persistence of AF, left atrium EF value, A peak and LAEF gradually decreased, left atrial EF decreased significantly after 1 week AF (P <0.05), A peak and LAEF decreased significantly AF2 (P <0.05), E / A value increased gradually, significantly increased after 2 weeks AF (P <0.05); E peak had no significant change. Conclusion: Continuous AF can cause left and right atrial enlargement, left atrial dysfunction.