论文部分内容阅读
尿毒症性神经病变的病因和发病机理至今尚未明了,本文作者报道9例长期作血液透析达2～10年之久。本组有4例尿毒症患者有脑病及周围神经病变,其余5例仅有周围神经病变。所有病人均以相同形式作生物素治疗。生物素的剂量为每日10mg分成三次服,用药1～4年。一天用量大约是人体每天需要量的100倍。在尿毒素病人中用此大剂量,是为了克服肠道菌群的生物素合成的抑制和吸收。大剂量生物素可越过肠道粘膜而被动地吸收。在生物素-依赖的全羧合成酶缺乏的病人中每天口服10mg可达血液的治疗水平。人和动物长期口服或注射过生物素并无妨碍。
The etiology and pathogenesis of uremic neuropathy is still unclear, the authors reported 9 cases of long-term hemodialysis for 2 to 10 years. This group of 4 patients with uremia encephalopathy and peripheral neuropathy, the remaining 5 cases only peripheral neuropathy. All patients treated biotin in the same format. Biotin dosage is divided into three daily doses of 10mg, medication 1 to 4 years. The daily dosage is about 100 times the daily requirement of the human body. In this large dose of uremic patients, is to overcome the inhibition and absorption of biotin synthesis of intestinal flora. Large doses of biotin can be passively absorbed across the intestinal mucosa. Therapeutic levels of 10 mg reachable blood are orally administered daily in patients with biotin-dependent carboxycarboxylase deficiency. Long-term oral administration of biotin to humans and animals does not prevent this.