【摘 要】
：
We previously reported that the increased expression of Dickkopf-related protein 1(DKK1)is positively related to vascular endothelial growth factor in the synovial fluid from patients with temporomandibular joint disorders(TMDs).DKK1 is involved in angiog
【机 构】
：
Department of Stomatology, Renmin Hospital of Wuhan University, Wuhan 430060, China
论文部分内容阅读
We previously reported that the increased expression of Dickkopf-related protein 1(DKK1)is positively related to vascular endothelial growth factor in the synovial fluid from patients with temporomandibular joint disorders(TMDs).DKK1 is involved in angiogenic activities in the TMD synovium in vitro,but the expression of DKK1 after treatment of TMD-osteoarthritis(TMD-OA)with hyaluronic acid(HA)remains unknown.In this study,we assessed the expression of DKK1 in the synovial fluid of TMD-OA patients before and after treatment with HA via enzyme-linked immunosorbent assay.We also investigated the role of DKK1 in TMD-OA via immunohistochemical staining.The relationship between the expression of DKK1 and the clinicopathological characteristics was determined by Pearson analysis.The results showed that the expression of DKK1 was significantly decreased after treatment with HA.Correlation analyses indicated that the expression of DKK1 in the TMD-OA samples was closely correlated with mouth opening and pain.These findings suggest that DKK1 could play an important role in the pathogenesis and treatment of TMD.Reduction of the pain by HA treatment may be correlated with the decreased expression of DKK1.
其他文献
采用JZCK-600F型多功能镀膜设备制备了Fe-Ga合金薄膜,研究了溅射工艺对Fe-Ga合金薄膜沉积速率及表面形貌的影响.用SEM、EDS研究了Fe-Ga合金薄膜的表面形貌和薄膜成分.当其他工艺参数不变时,溅射时间、溅射功率是影响Fe-Ga合金薄膜的厚度和生长速率的主要因素.随溅射时间和功率的增加,薄膜厚度和沉积速率也随之增加,并且薄膜厚度与溅射时间和功率呈现出正比例关系;但是薄膜厚度过大,加大的内应力会使薄膜剥离.溅射功率过大时,内应力同样会使薄膜内部出现裂纹.所制备Fe-Ga合金薄膜的磁畴图像明暗对
采用光学显微镜、激光共聚焦扫描电镜等研究了 450℃固溶处理不同时间后Mg-Zn-Mn-Y合金的微观组织和去除腐蚀产物后的表面腐蚀形貌,通过动态腐蚀质量损失法研究了合金在模拟人体体液中的降解行为,用电化学工作站研究了其电极腐蚀动力学过程.结果表明,随着固溶时间的增加,合金组织中的第二相减少,晶粒逐渐粗化,合金的腐蚀方式由局部腐蚀转变为均匀腐蚀.固溶处理18 h时的合金耐蚀性最好,动态质量损失平均腐蚀速率、自腐蚀电流密度分别为(0.418±0.027)mm/y、11.34 μA/cm2.
Yu Gan Long(YGL)is a Chinese traditional herbal formula which has been reported to attenuate liver fibrosis for many years and we have explored its anti-fibrotic mechanism through blocking transforming growth factor(TGF-β)in the previous study.But the mec
Acute focal cerebral ischemic stroke(IS)is a leading cause of morbidity and mortality worldwide.Acupuncture is an emerging alternative therapy that has been beneficial to acute brain ischemia.However,the underlying protective mechanism of its neuroprotect
Cerebellar degeneration-related antigen 1(CDR1)was described to be expressed in the nervous system and in different types of cancer tissues.In the present study,we demonstrate that CDR1 is in addition ubiquitously expressed in human epidermis,dermis and i
借助金相检验相关知识,对某型号内燃机活塞进行了宏观组织和显微组织分析.结果表明:活塞基体部位分散性孔洞为1级,集中性孔洞为1级;复合材料部位分散性孔洞为1级,集中性孔洞为1级;活塞试样组织中α固溶体较大,共晶硅呈短条状,部分呈小块状,初晶硅呈中等块状,略有聚集,评定为3级;鱼骨状铁相夹杂物及针状铁相夹杂物不明显,铁相夹杂物评定为1级.
铜合金材料作为高新技术产业的主流材料,需同时具备高强高导的性能.但是根据不同的应用环境,在保持高导电率的前提下如何选择合适的强化方法是制备铜合金的瓶颈.据研究可知,合金化法(形变强化、时效强化、固溶强化、细晶强化)和复合材料法(人工复合材料法、自身复合材料法)可以提高铜合金材料强度,但对其导电率有一定的影响.通过添加稀土元素、快速凝固法或大塑性变形等强化方法,有望获得高强度、高导电率的铜合金.本文着重探讨了合金化法和复合材料法的强化机理及其优缺点,并对铜合金的研究热点进行讨论和展望.
Female infertility after occupational exposure to inhaled anesthetic agents has attracted critical attention,but systematic studies focusing on the impact of inhaled anesthetics on the female reproductive system have not been well-established.We used a mu
This study aimed to construct a quality management model for phase Ⅰ clinical drug trials.A cross-sectional survey was conducted and data were collected from 604 respondents at 69 institutions in China engaged in phase Ⅰ clinical drug trials.Exploratory a