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目的：研究石杉碱甲对东莨菪碱和蝇蕈醇所致记忆障碍的改善作用.方法：采用小鸡的一次性被动回避学习模型研究记忆形成过程，辨别率作为评价记忆保持水平的指标.结果：学习前5分钟，双侧上纹体腹核(hyperstriatum ventral HV)内注射东莨菪碱100ng或蝇蕈醇50ng显著降低小鸡的逃避率.学习前15分钟，双侧HV内注射石杉碱甲25 ng能明显逆转东莨菪碱和蝇蕈醇所致记忆损害.结论：石杉碱甲在改善记忆形成的过程中，除了通过高选择性抑制乙酰胆碱脂酶外，还与调节GABAA受体有密切关系.“,”AIM: To study the effects of huperzine A on disruption of spatial memory induced by scopolamine (a muscarinic antagonist ) and muscimol ( a GABAA agonist) in passive avoidance task. METHODS: One-trial passive avoidance task was used to investigate the effects of huperzine A. The avoidance rate was used to evaluate memory retention. RESULTS: Both scopolamine ( 100 ng) and muscimol (50 ng), injected intracranially 5 min before training, resulted in a decreased avoidance rate. Huperzine A (25 ng), injected intracranially 15 min before training, reversed memory deficits induced by scopolamine and muscimol at 30 min after training, and this reversal persisted at least 1 h. The improving effects of huperzine A exhibited a bell-shaped dose-response curve.CONCLUSION: Huperzine A improved the process of memory formation not only by acting as a highly potent and selective inhibitor of ACHE, but also by antagonizing effects mediated through the GABAn receptor.