本文报告用免疫学和分子生物学方法对28例畸形儿产妇,10例畸形儿及其母亲,75例婴儿肝炎综合征进行弓形虫检测。23例产妇血清弓形虫抗体阳性率48%,10例畸形儿母亲血清抗体阳性率90%,而畸形儿弓形虫DNA杂交及动物接种分离弓形虫阳性率分别为70%和80%。婴儿肝炎综合征血清抗体阳性率9.8%,上述阳性率均显著高于正常人群弓形虫血清抗体阳性率。说明弓形虫感染是导致胎儿致畸及婴儿肝炎综合征的重要病原之一。 This article reports the use of immunology and molecular biology methods of 28 cases of deformed maternal, 10 cases of deformed children and their mothers, 75 cases of infant hepatitis syndrome Toxoplasma detected. The positive rate of serum antibodies against Toxoplasma gondii in 23 maternal women was 48%, while that of 10 maternal children with deformity was 90%. The positive rates of Toxoplasma gondii DNA hybridization and Toxoplasma isolated from animals were 70% and 80% respectively. The positive rate of serum HBsAg was 9.8%, which was significantly higher than that of normal population. Toxoplasma gondii infection is one of the important pathogens causing fetal teratogenicity and infant hepatitis syndrome.