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目的:探讨益气温阳方通过诱导Treg细胞变化,使变应性鼻炎的机体产生免疫耐受,达到治疗目的。方法:本研究将SD大鼠分为空白组、模型组和益气温阳方组,建立变应性鼻炎大鼠模型,并予以益气温阳方灌胃,结束后取脾组织标本,借助流式细胞仪检测标本的CD4+CD25+Treg和CD4+CD25+Foxp3+Treg数值。结果:经过单因素方差分析结合绘制均数图进行趋势分析表明:CD4+CD25+Treg细胞数值从正常组到模型组是下降的,经过益气温阳方治疗后回升,但未恢复到正常大鼠水平,与模型组相比未见显著差异。而CD4+CD25+Foxp3+Treg细胞数值从正常组到模型组是下降的,经过益气温阳方治疗后回升,且达到正常组水平,与模型组相比,有显著差异(P<0.01)。结论:益气温阳方可以上调变应性鼻炎大鼠的Treg细胞水平,增强其免疫耐受功能,从而改善变应性鼻炎症状。
OBJECTIVE: To investigate the effects of Yiqi Wenyang Recipe on the induction of Treg cells and immunological tolerance in allergic rhinitis patients. Methods: The SD rats were divided into blank group, model group and Yiyang Wenyangfang group to establish the rat model of allergic rhinitis, Cytometry samples were detected CD4 + CD25 + Treg and CD4 + CD25 + Foxp3 + Treg values. Results: The single factor analysis of variance with the average number of plots for trend analysis showed that: CD4 + CD25 + Treg cell number from the normal group to the model group is decreased, after Yiqi Wenyang Fang treatment rose, but did not return to normal rats Level, no significant difference compared with the model group. The number of CD4 + CD25 + Foxp3 + Treg cells decreased from the normal group to the model group. After the treatment with Yiqi Wenyang Decoction, the numbers of CD4 + CD25 + Foxp3 + Treg cells rose and reached the level of the normal group, which was significantly different from the model group (P <0.01). Conclusion: Yiqi Wenyang Recipe can upregulate the Treg cell level in allergic rhinitis rats and enhance its immune tolerance function, so as to improve the symptoms of allergic rhinitis.