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目的:观察化痰清肺汤对支气管肺炎患者的临床疗效及机体炎症反应的影响。方法:本试验共收集年龄在5~12岁之间的支气管肺炎临床患者50例,并采用数字随机方法将患者分为治疗组25例和对照组25例。对照组采用西医基础治疗,治疗组在对照组基础上加用化痰清肺汤口服,疗程均为10天。观察两组治疗前后中医症状积分改善情况及白细胞计数、外周血中性粒细胞百分比、白介素~8(IL-8)、肿瘤坏死因子-α(TNF-α)、白介素~17(IL-17)等相关炎症指标变化。结果:1)治疗组总有效率96%,对照组总有效率84%,组间比较差异具有统计学意义(P<0.05)。2)治疗后两组临床症状积分较治疗前明显下降(P<0.05),且治疗组下降更显著(P<0.05);3)治疗后,两组WBC、中性粒细胞较治疗前下降明显(P<0.05),且治疗组下降水平更显著(P<0.05);4)治疗后,两组症状消失时间相比,具有统计学意义(P<0.05);5)治疗后,治疗组外周血IL-8、TNF-α和IL-17水平与对照组相比,下降水平有明显差异,有统计学意义(P<0.05)。6)治疗后,治疗组与对照组的肺功能、呼吸生活质量相比,具有统计学意义(P<0.05)。结论:化痰清肺汤治疗支气管肺炎效果较好,作用机制与本方能够有效抑制炎症因子有关。
Objective: To observe the clinical efficacy of Huatan Qingfei Decoction on patients with bronchial pneumonia and the impact of the body’s inflammatory response. Methods: A total of 50 clinical cases of bronchopneumonia aged 5 to 12 years old were collected and divided into treatment group (25 cases) and control group (25 cases) by digital random method. The control group was treated with Western medicine. The treatment group was treated with Huatan Qingfei decoction on the basis of the control group, both for 10 days. The improvement of symptom scores and the number of leukocytes, the percentage of neutrophils in peripheral blood, the levels of interleukin-8, tumor necrosis factor-α (TNF-α), interleukin 17 (IL-17) And other related indicators of inflammation. Results: 1) The total effective rate was 96% in the treatment group and 84% in the control group, with statistical significance (P <0.05). 2) After treatment, the scores of clinical symptoms in two groups were significantly decreased (P <0.05), and the treatment group decreased more significantly (P <0.05); 3) After treatment, WBC and neutrophil decreased significantly in both groups (P <0.05), and the treatment group decreased more significantly (P <0.05); 4) After treatment, the disappearance of symptoms between the two groups was statistically significant (P <0.05); 5) After treatment, The levels of IL-8, TNF-α and IL-17 in blood were significantly lower than those in control group (P <0.05). 6) After treatment, the lung function and respiratory quality of life in the treatment group and the control group were statistically significant (P <0.05). Conclusion: Huatan Qingfei Decoction is effective in the treatment of bronchial pneumonia, and the mechanism of action is related to the effective inhibition of inflammatory factors.