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目的研究端粒酶逆转录酶(human telomerase reverse transcriptase,hTERT)在胃腺癌组织和胃良性病变组织中的表达特征,探讨hTERT与胃腺癌生物学行为的关系。方法采用免疫组化的方法,检测45例胃腺癌、14例胃溃疡、16例慢性胃炎及11例正常对照者胃镜活检标本中hTERT的表达,并通过IPP软件对图片进行图像分析,结合随访获得的临床资料进行统计学分析。结果 hTERT在正常胃黏膜、慢性胃炎、胃溃疡组织中表达的IOD值分别为(119.44±54.12),(159.94±78.67),(266.55±81.84),三组之间无显著差异(P>0.05),但正常胃黏膜与胃腺癌[早期:(3129.88±634.34),进展期:(5288.45±1303.64)]差异有显著性(P<0.01)。hTERT的表达程度与胃腺癌的分化程度、浸润深度、淋巴结转移、远处转移、临床分期及病理类型有密切关系(P<0.05),与年龄、性别及肿瘤部位无明显关系(P>0.05)。结论hTERT与胃腺癌的发生、转移、预后有重要关系。
Objective To investigate the expression of hTERT in gastric adenocarcinoma and gastric benign lesions and to explore the relationship between hTERT and the biological behavior of gastric adenocarcinoma. Methods Immunohistochemical method was used to detect the expression of hTERT in 45 cases of gastric adenocarcinoma, 14 cases of gastric ulcer, 16 cases of chronic gastritis and 11 cases of normal controls. The images were analyzed by IPP software and followed up The clinical data for statistical analysis. Results The IOD values of hTERT in normal gastric mucosa, chronic gastritis and gastric ulcer tissues were (119.44 ± 54.12), (159.94 ± 78.67) and (266.55 ± 81.84), respectively, with no significant difference among the three groups (P> 0.05) , But there was a significant difference between normal gastric mucosa and gastric adenocarcinoma [early stage (3129.88 ± 634.34), advanced stage (5288.45 ± 1303.64)] (P <0.01). The expression of hTERT was closely related to the degree of differentiation, depth of invasion, lymph node metastasis, distant metastasis, clinical stage and pathological type of gastric adenocarcinoma (P <0.05), but not to age, sex and tumor location (P> 0.05) . Conclusion hTERT has an important relationship with the occurrence, metastasis and prognosis of gastric adenocarcinoma.