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以甲苯二异氰酸酯(TDI)中的-NCO基与纳米金属氧化物表面的羟基发生反应,得到改性纳米金属氧化物,并使其与肝素钠(Heparin)进行接枝反应生成肝素杂化材料,结合红外、热重、扫描电镜(SEM)等表征方法,确定纳米金属氧化物确实接枝到了肝素钠的表面。通过对体外凝血时间和复钙时间的测定,来初步研究肝素杂化材料的抗凝血性质。结果表明:肝素杂化材料的抗凝血时间和复钙时间均比肝素钠的要短,表明它的抗凝血性比肝素钠的抗凝血性要弱一些;但比纳米金属氧化物和空白组的抗凝血时间和复钙时间要长,说明肝素杂化材料的抗凝血性与其相比则有明显的提高。
The reaction of -NCO groups in toluene diisocyanate (TDI) with hydroxyl groups on the surface of nano-metal oxide to obtain a modified nano-metal oxide and grafting reaction with Heparin to produce heparin hybrid material, Combined with infrared, thermogravimetry, scanning electron microscopy (SEM) and other characterization methods to determine the nano-metal oxide is indeed grafted to the surface of sodium heparin. The anticoagulant properties of heparin hybrid materials were preliminary studied by measuring the clotting time in vitro and the time of calcium complexation. The results showed that the anticoagulant time and calcium recalcification time of heparin hybrid materials were shorter than that of heparin sodium, indicating that the anticoagulant activity of heparin hybrid material was weaker than that of heparin sodium. However, Of the anticoagulant time and calcium complex longer, indicating that the anticoagulant heparin hybrid material compared with the obvious increase.