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白细胞介素-1(IL-1)是一组多功能的细胞因子,在免疫反应、炎症、发热和急性期蛋白合成等诸多防御反应中起作用。在脑缺血/再灌流损伤中,白细胞释放的化学介质有重要作用,且梗塞的大小及预后和白细胞浸润的多少关系密切。McClain报道在脑外伤患者脑脊液中可检出IL-1,Minami等证实大鼠短暂性额叶脑缺血后IL-1βmRNA表达增多,这充分说明IL-1是一种参与脑外伤和缺血性脑损伤的炎性介质。但对脑
Interleukin-1 (IL-1) is a group of multifunctional cytokines that play a role in many defense responses such as immune response, inflammation, fever and acute phase protein synthesis. In cerebral ischemia / reperfusion injury, the white blood cell release of chemical mediators have an important role, and the size and prognosis of infarction and the number of leukocyte infiltration is closely related. McClain reports that cerebrospinal fluid can be detected in patients with traumatic brain injury IL-1, Minami and other confirmed after transient forebrain ischemia in rats IL-1βmRNA expression increased, which fully shows that IL-1 is involved in a traumatic brain injury and ischemic Brain injury of the inflammatory mediators. But on the brain