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目的分析慢性阻塞性肺疾病(COPD)急性加重患者合并肺部真菌感染的临床表现、病原学分布及危防治对策。方法回顾性分析52例COPD患者机械通气后并发下呼吸道真菌感染患者的临床资料。结果患者临床表现均无特异性,肺部真菌感染中以念珠菌属为主,氟康唑治疗有效率98.1%。结论COPD急性加重并发肺部真菌感染率高,念珠菌属是主要致病菌,氟康唑治疗效果最好。
Objective To analyze the clinical manifestations, etiological distribution and prevention and treatment of pulmonary fungal infection in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods The clinical data of 52 patients with COPD undergoing mechanical ventilation and lower respiratory tract fungal infection were retrospectively analyzed. Results The clinical manifestations of patients were nonspecific. Candida species was the main cause of pulmonary fungal infection, and fluconazole treatment efficiency was 98.1%. Conclusion The acute exacerbation of COPD is associated with a high rate of pulmonary fungal infection. Candida is the main pathogen and fluconazole is the best.