论文部分内容阅读
用发色底物法及酶联免疫法测定脑梗塞急性期患者和健康人血浆中ｔ－ＰＡ、ＰＡＩ－１和ＶＷＦ三者活性，目的为研究这３种物质的活性水平及早晚变化规律在两组间的差异，并探讨其与脑梗塞发病间的关系。结果显示两组中ｔ－ＰＡ活性早晨低，下午高；ＰＡＩ－１活性早晨高，下午低，两者活性呈负相关。观察组早晨ｔ－ＰＡ活性明显低于对照组；ＰＡＩ－１和ＶＷＦ活性则明显高于对照组（Ｐ＜０．０１）。上述变化与脑梗塞清晨发病率高同步。
The activity of t-PA, PAI-1 and VWF in the plasma of patients with acute cerebral infarction and healthy volunteers were assayed by chromogenic substrate method and enzyme-linked immunosorbent assay (ELISA) in order to study the changes of activity and early and late changes of these three substances The difference between the two groups and to explore its relationship with the incidence of cerebral infarction. The results showed that t-PA activity in both groups was low in the morning and high in the afternoon. PAI-1 activity was high in the morning and low in the afternoon, and the activity of both was negatively correlated. The activity of t-PA in the observation group was significantly lower than that in the control group. The activity of PAI-1 and VWF in the observation group was significantly higher than that in the control group (P <0.01). The above changes and cerebral infarction early morbidity synchronization.