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目的 :探讨贲门癌围手术期血清睾丸酮水平变化及其临床意义。方法 :应用放射免疫法测定男性正常人 89例 ,贲门癌手术治疗患者 184例的血清睾丸酮水平。结果 :男性贲门癌术前血清睾丸酮明显低于正常人 (P<0 .0 0 1) ,探查组低于手术切除组 (P<0 .0 1) ,切除术后明显升高 (P<0 .0 1) ;浸润浆膜外组织、病灶 >5 cm、淋巴结癌转移者分别较肌层、≤ 5 cm、无转移者为低 (P<0 .0 5 )。结论 :血清丸睾酮可作为男性贲门癌术前判断病变程度的参考指标 ,病灶越大、外侵越明显或伴有淋巴结转移 ,血清睾丸酮水平越低。
Objective: To investigate the changes of serum testosterone levels in patients with cardiac cancer and its clinical significance. METHODS: Serum testosterone levels in 184 male and female patients with cardiac cancer were measured by radioimmunoassay. RESULTS: Preoperative serum testosterone was significantly lower in men than in normal subjects (P < 0.01), and it was lower in the exploratory group than in the surgical resection group (P <0. 01) and significantly higher after resection (P < 0). .0 1) Infiltration of extraserosal tissue, lesions >5 cm, lymph node metastasis was lower than that of muscle, ≤ 5 cm, and non-metastatic (P < 0.05). Conclusion: Serum testosterone can be used as a reference index to determine the degree of precancerous lesions of male cardiac cancer. The larger the lesion, the more aggressive it is, or the lymph node metastasis, the lower the serum testosterone level.