目的分析了探讨经单鼻蝶入路手术治疗垂体腺瘤的疗效和并发症。方法收治20例垂体腺瘤患者,其中5例患者为微腺瘤,15例患者为大腺瘤,8例患者为泌乳素腺瘤,6例患者为生长激素腺瘤,5例患者为泌乳素和生长激素混合性腺瘤,1例患者为无功能性腺瘤。结果所有患者在显微镜下进行手术,完全切除18例,次完全切除2例。手术后有10例患者出现一过性尿崩症,经过3 d治疗后患者基本恢复。手术无死亡病例,无术区出血以及脑膜炎等并发症。患者手术后住院时间为6～12 d,平均住院7 d,20例患者手术过程中没有输血患者;随访1～6年,无复发病例。结论经单鼻蝶入路手术治疗垂体腺瘤疗效显著,且手术创伤较小,操作简单,并发症较少,值得临床推广使用。 Objective To analyze the curative effect and complications of pituitary adenoma treated by single nasal butterfly approach. Methods Twenty patients with pituitary adenomas were enrolled. Among them, 5 were microadenomas, 15 were macroadenomas, 8 were prolactinomas, 6 were growth hormone adenomas, and 5 were prolactin And growth hormone mixed adenoma, 1 patient was non-functional adenoma. Results All the patients underwent microsurgical operation, with complete resection in 18 cases and complete resection in 2 cases. Ten patients had transient diabetes insipidus after surgery, and the patients recovered after 3 days. There were no deaths, no bleeding in operation and meningitis. The patient’s postoperative hospital stay was 6-12 days, with an average hospitalization of 7 days. No patients were transfused during the operation of 20 cases. No recurrence was observed after 1-6 years of follow-up. Conclusions The treatment of pituitary adenoma through single nasalis patellar approach is effective and has less trauma and simple operation with less complications. It is worthy of clinical application.