本文对庆大霉素(GENT)与羧苄青霉素(CBC)合用在健康成人体内的药动学进行了研究,以探索CBC对GENT药动学的影响。受试者7人,男4人,女3人,年龄21-48岁,肝、肾功能均正常,以自身对照先后进行两组实验,间隔14天。单用组:恒速静滴GENT12万u,分别于停药不同时间手指微量取血并从滴注开始时收集24h尿液;合用 In this paper, the pharmacokinetics of gentamicin combined with carbenicillin (CBC) in healthy adults were studied in order to explore the effect of CBC on GENT pharmacokinetics. Subjects 7, 4 males and 3 females, aged 21-48 years old, liver and kidney function were normal to their own control has conducted two groups of experiments, an interval of 14 days. Single-use group: constant infusion GENT12 million u, respectively, at different times during the withdrawal of finger micro-blood and 24h urine collection from the beginning of infusion;