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目的 研制头颅半约束非撞击弥漫性轴索损伤 (DAI)动物模型 ,评价该模型的可行性。方法 根据球面交链原理 ,研制出猫头颅半约束非撞击三维旋转暴力DAI致伤装置 ,用加速传感器测试损伤参数 ,神经丝蛋白亚基 (NF6 8kD)免疫组化检测损伤轴索分布 ,三维有限元方法分析损伤应力分布。结果 3kg重锤自 3m高度撞击测得角加速度 1 37× 10 6rad/s2 ,加速时间 3 91± 0 6 9ms ,角减速度 1 45× 10 5rad/s2 ,减速时间 3 6 7± 1 10ms ,脑内轴索球分布与应力分布吻合。结论 头颅半约束非撞击致伤装置可致猫DAI,兼有头颅全约束非撞击和非约束撞击DAI动物模型的一些特点
Objective To develop a semi-constrained, non-impact diffuse axonal injury (DAI) animal model and evaluate the feasibility of this model. Methods According to the principle of spherical cross linking, a three-dimensional rotational non-impact DAI injury device was developed by using a semi-constrained, non-impact, and three-dimensional rotationally damaging DAI device. The acceleration parameters were used to test the damage parameters. Neurofilament subunit (NF6 8kD) immunohistochemistry was used to detect axonal distribution. Meta - method to analyze damage stress distribution. Results The angular acceleration of 3kg hammer was 377 × 10 6 rad / s 2, the acceleration time was 3 91 ± 0 6 9 ms, the angular deceleration was 1 45 × 10 5 rad / s 2, the deceleration time was 3 6 7 ± 1 10 ms The inner ball and ball distribution match with the stress distribution. CONCLUSIONS: The semi-constrained non-impact head injury device can cause DAI in cats, and has some characteristics of a fully constrained skull and a non-restrained impact DAI animal model