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目的 观察自体髓核组织对神经根的影响。 方法 成年家兔 30只 ,随机分成实验组和对照组 ,每组又分为术后 1,3,7d组 ,各 5只。实验组在兔L6 ,7间盘纤维环上钻孔 ,使髓核组织通过渗漏与邻近神经根相接触 ;对照组保持纤维环完整。术后 1,3,7d ,以电生理方法观察各组神经根传导功能的动态变化 ,同时观察神经根的组织学及超微结构。 结果 术后 1,3 ,7d ,实验组神经根传导速度逐渐下降 ,分别为 (6 0 .12± 0 .71)m s、(4 9.6 3± 1.0 7)m s、(30 .76± 1.36 )m s ;神经纤维发生轻微病理改变。术后 3d ,电镜下可见雪旺细胞肿胀 ;术后 7d ,还可见部分神经纤维的施兰切迹增大。 结论 单纯将纤维环切开 ,髓核组织通过渗漏可使邻近神经根结构与功能发生改变 ,造成非机械性神经根损伤
Objective To observe the effect of autologous nucleus pulposus on nerve root. Methods Thirty adult rabbits were randomly divided into experimental group and control group. Each group was divided into three groups: 1, 3 and 7 days after operation. The experimental group in rabbit L6, 7 disc annulus drilling, the nucleus pulposus through leakage and adjacent nerve root contact; control group to maintain the integrity of the annulus fibrosus. At 1, 3 and 7 days after operation, the dynamic changes of nerve root conduction function in each group were observed by electrophysiological method, and the histology and ultrastructure of nerve root were observed. Results At 1, 3 and 7 days after operation, the conduction velocity of nerve root in experimental group decreased gradually (60.12 ± 0.71) ms, (4.96 ± 1.07) ms and (30.76 ± 1.36) ms respectively Slight pathological changes in nerve fibers. After 3 days, the swelling of Schwann cells was observed under electron microscope. On the 7th day after operation, some of the nerve fibers also showed an increase in the number of smears. Conclusions The annulus fibrosus is simply incised and the nucleus pulposus can change the structure and function of adjacent nerve roots through leakage, resulting in non-mechanical nerve root injury