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作者从单核、淋巴因子的角度探讨了Ｔａｍｍ－Ｈｏｒｓｆａｌｌ蛋白（ＴＨＰ）与免疫系统的关系，以及ＴＨＰ通过自身免疫反应诱发肾小管间质性肾炎（ＴＩＮ）的机制。系列研究的结果提示，在生理状态下。ＴＨＰ可能参于了肾脏对某些细胞因子，诸如白细胞介素１、白细胞介素２和肿瘤坏死因子的清除与代谢。当某些病理状态致ＴＨＰ直接进入肾间质时，则可能通过激发细胞免疫反应导致ＴＩＮ。单核／巨噬细胞及其分泌的某些单核因子是介导这类ＴＩＮ组织炎症和纤维化的关键因素。这一结论不仅有助于进一步阐明ＴＨＰ的病理生理作用。同时也可能给某些ＴＩＮ的治疗以新的启示。
The authors investigated the relationship between Tamm-Horsfall protein (THP) and the immune system and the mechanism of THP induced tubulointerstitial nephritis (TIN) through the autoimmune response from the perspective of mononuclear and lymphokine. The results of a series of studies suggest that under physiological conditions. THP may be involved in the kidney’s clearance and metabolism of certain cytokines, such as interleukin-1, interleukin-2 and tumor necrosis factor. When certain pathological conditions cause THP to directly enter the renal interstitium, TIN may be induced by stimulating the cellular immune response. Monocytes / macrophages and certain monokines secreted by them are the key factors mediating the inflammation and fibrosis of such TIN tissues. This conclusion not only helps to further clarify the pathophysiological role of THP. It may also give new insights into the treatment of certain TINs.