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目的探讨脑梗死发病后血浆内皮素（ＥＴ）及一氧化氮（ＮＯ）动态变化及与脑梗死的关系。方法采用放射免疫测定法及比色法对 ３８例急性期脑梗死患者在发病后 ６ｈ内、 ６ｈ后、 ２４ｈ、３ｄ、５ｄ、７ｄ连续测定其血浆ＥＴ、ＮＯ浓度。结果脑梗死发病６ｈ后至７ｄ前血浆ＥＴ、ＮＯ均显著高于正常对照组（Ｐ<０．０５～０．０１），两者浓度均在发病６ｈ后始增高（Ｐ<０ ．０５），２４ｈ达高峰（Ｐ<０．０１），持续３ｄ后始下降，７ｄ后接近于正常（Ｐ＞０．０５），两者呈显著正相关性（Ｐ<０．０１）。有高血压、糖尿病史者其血浆ＥＴ、ＮＯ浓度明显高于无两病史者（Ｐ<０．０５～０．０１）、结论ＥＴ和ＮＯ是致脑梗死发展的重要因素，ＥＴ、ＮＯ的动态变化为临床有效治疗脑梗死及选择治疗时机有指导意义。
Objective To investigate the changes of plasma endothelin (ET) and nitric oxide (NO) after cerebral infarction and its relationship with cerebral infarction. Methods The radioimmunoassay and colorimetric method were used to measure the levels of plasma ET and NO in 38 patients with acute cerebral infarction at 6h, 24h, 3d, 5d, 7d after onset. Results The levels of ET and NO in plasma from 6h to 7d after onset of cerebral infarction were significantly higher than those of normal control group (P <0.05 ~ 0.01). The concentrations of both were increased at 6h after onset (P <0.05) (P <0.01), and then decreased from the third day to the third day and reached the normal level after 7 days (P <0.05). There was a significant positive correlation between them (P <0.01). The plasma ET and NO levels in patients with history of hypertension and diabetes mellitus were significantly higher than those without history of both diseases (P <0.05 ~ 0.01). Conclusion ET and NO are important factors in the development of cerebral infarction. The dynamic changes of ET and NO Changes for the clinical treatment of cerebral infarction and the timing of treatment has instructive significance.