1例57岁男性患者因急性心肌梗死行冠状动脉支架置入术。术后给予阿司匹林100 mg,1次/d口服;氯吡格雷75 mg,1次/d口服;辛伐他汀40 mg,1次/d睡前口服。第5天患者出现右下肢酸痛。第8天肌酸激酶2085 U/L,血清肌酐187μmol/L,同时出现尿色加深,尿潜血(+)。停用辛伐他汀,继续使用阿司匹林及氯吡格雷,同时给予辅酶Q10口服。停药第2天患者右下肢酸痛症状明显缓解,肌酸激酶1337 U/L。停药第11天,其肌酸激酶降至186 U/L,血清肌酐101μmol/L,遂出院。 A 57-year-old male underwent coronary stenting for acute myocardial infarction. Postoperative aspirin 100 mg, 1 / d orally; clopidogrel 75 mg, 1 / d orally; simvastatin 40 mg, 1 time / d orally before bedtime. On the fifth day, the patient developed right lower extremity soreness. 8th day creatine kinase 2085 U / L, serum creatinine 187μmol / L, at the same time darker urine, urine occult blood (+). Stop using simvastatin, continue to use aspirin and clopidogrel, given coenzyme Q10 orally. On the second day after stopping, the symptoms of right lower extremity pain were relieved, and creatine kinase 1337 U / L. On the 11th day of withdrawal, the creatine kinase was reduced to 186 U / L and serum creatinine was 101 μmol / L, then discharged.