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对ＢＡＬＢ／ｃ小白鼠甲状腺滤泡上皮细胞从胚胎１４ｄ（Ｅ１４ｄ）至成年期的发育过程，进行了组织化学与立体计量学研究。结果表明：（１）Ｅ１４ｄ～１５ｄ，细胞排列成不规则的团和索状。Ｅ１６ｄ～Ｅ１７ｄ，细胞围成原始的甲状腺滤泡。Ｅ１８ｄ，滤泡腔内出现ＰＡＳ反应阳性胶体，成熟的甲状腺滤泡结构基本形成。（２）胚胎期滤泡上皮细胞核较大，核／质比大于１．０，分裂像易见。出生后２１ｄ，核／质比稳定在０．３５，滤泡上皮细胞形态结构接近成年期状态。（３）Ｅ１６ｄ，ＡｃＰ、ＡＴＰａｓｅ、ＭＡＯ和ＳＤＨ均呈阳性反应，随后酶活性逐步增强，至生后２１ｄ均达强阳性反应。
Histochemistry and stereometrical studies were performed on the development of thyroid follicular epithelial cells from embryonic day 14 (E14d) to adulthood in BALB / c mice. The results showed that: (1) E14d ~ 15d, the cells arranged in irregular clusters and cord-like. E16d ~ E17d, cells surrounded by the original thyroid follicles. E18d, PAS-positive colloid in the follicular cavity, mature thyroid follicular structure basically formed. (2) Embryonic follicular epithelial cells larger nuclear, nuclear / mass ratio greater than 1.0, split like easy to see. At 21 days after birth, the nuclear / cytosolic ratio was stable at 0.35. The follicular epithelial cell morphology was close to that of adulthood. (3) E16d, AcP, ATPase, MAO and SDH were positive reaction, then gradually increased enzyme activity, to 21d postpartum were strong positive reaction.