伊立替康适用于晚期结肠癌、直肠癌的一线治疗,也可用于术后辅助治疗。对肺癌、乳腺癌、胰腺癌、胃癌、宫颈癌和卵巢癌等有一定疗效。伊立替康联合顺铂或卡铂是广泛期小细胞肺癌可选择的一线治疗方案~[1]。有报道认为40%的患者可能出现3~4度腹泻,并导致化疗方案提前中止~[2],发生腹泻的时间约在用药后第5天出现~[3],故使用伊立替康化疗的患者, Irinotecan for advanced colon cancer, first-line treatment of rectal cancer can also be used for postoperative adjuvant therapy. On lung cancer, breast cancer, pancreatic cancer, stomach cancer, cervical cancer and ovarian cancer have a certain effect. Irinotecan combined with cisplatin or carboplatin is the first-line treatment of extensive-stage small cell lung cancer treatment options ~ [1]. It is reported that 40% of patients may have 3-4 degrees of diarrhea and lead to early termination of chemotherapy program ~ [2], diarrhea occurred in about 5 days after treatment ~ 3, so the use of irinotecan chemotherapy patient,