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目的:探讨丁香胃灵合剂(CWLM)对慢性萎缩性胃炎大鼠(CAG)胃黏膜及Bcl-2蛋白表达的影响。方法:光镜下观察大鼠胃黏膜病理组织学改变,免疫组化方法检测大鼠胃黏膜Bcl-2蛋白的表达。结果:CAG对照组标本胃黏膜腺体大部分萎缩消失,伴有炎性细胞浸润,CWLM各治疗组与CAG对照组比较病理形态有明显好转,已接近正常对照组。CAG对照组Bcl-2阳性表达指数明显高于正常对照组,差异有显著意义(P<0.01);CWLM各治疗组Bcl-2阳性表达指数明显下降,与CAG对照组差异有显著意义(P<0.01)。结论:丁香胃灵合剂对Bcl-2蛋白表达水平具有调节作用,可抑制CAG大鼠胃黏膜细胞的过度增殖,可逆转CAG胃黏膜的病理改变。
Objective: To investigate the effects of clover stomach mixture (CWLM) on gastric mucosa and Bcl-2 protein expression in chronic atrophic gastritis rats (CAG). Methods: The histopathological changes of gastric mucosa were observed under light microscope. The expression of Bcl-2 protein in gastric mucosa was detected by immunohistochemistry. Results: Most of gastric mucosal glands of CAG control group disappeared and accompanied with infiltration of inflammatory cells. Compared with CAG control group, the pathological changes of CWLM treatment group were obviously improved and they were close to the normal control group. The positive expression of Bcl-2 in CAG control group was significantly higher than that in normal control group (P <0.01). The expression of Bcl-2 positive index in CWLM treatment group was significantly lower than that in CAG control group (P < 0.01). Conclusion: Ding Xiang Wei Ling mixture can regulate the expression of Bcl-2 protein, inhibit the excessive proliferation of gastric mucosal cells in CAG rats, and reverse the pathological changes of CAG gastric mucosa.