目的探讨组织型纤溶酶原激活剂（ｔＰＡ）的对眼内出血的治疗作用及并发症。方法常规方法治疗无效的眼内出血者１４例（１４眼），４例前房出血行前房注射。９例玻璃体出血（ＶＨ）行玻璃体注射。１例暴发性脉络膜上腔出血后脉络膜上腔注射。结果追踪１～６月，平均２月，出血溶解１３例，视力提高１２例。并发症为眼压增高、再出血及房水混浊各２例。结论ｔＰＡ可促进眼内出血的溶解。 Objective To investigate the therapeutic effect and complications of tissue plasminogen activator (tPA) on intraocular hemorrhage. Methods 14 cases (14 eyes) were treated by conventional method for ineffective intraocular hemorrhage. Four cases of anterior chamber hemorrhage were injected into the anterior chamber. Nine cases of vitreous hemorrhage (VH) were performed with vitreous injection. One case had fulminant choroidal hemorrhage after choroidal injection. Results 1 to 6 months follow-up, the average February, 13 cases of hemolysis, visual acuity improved in 12 cases. Complications for intraocular pressure, rebleeding and aqueous turbidity in 2 cases. Conclusion t  PA can promote the dissolution of intraocular hemorrhage.