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报道9例子宫颈恶性腺瘤。血性和水样粘液性白带增多是最常见的临床症状。临床检查发现宫颈肥大和糜烂,4例可见宫颈息肉样或瘤样结节。镜下见宫颈腺体自鳞状—柱状上皮交界处以上一侧增生,数量增多,并沿水平方向扩展至子宫腔,同时浸润宫颈深层间质和子宫肌层。腺瘤上皮细胞呈单层排列,类似于正常宫颈管腺体,但可见部分形状不规则的胞核和大小不一的腺体,仔细观察将可见到核分裂象。患者预后和肿瘤临床分期密切相关。粘液组织化学和CEA免疫组织化学染色有助于鉴别诊断。
Reported 9 cases of cervical malignant adenoma. Bloody and watery mucous vaginal discharge is the most common clinical symptoms. Clinical examination revealed cervical hypertrophy and erosion, 4 cases of cervical polyps or tumor-like nodules. Microscopically, see the cervical gland from the squamous - columnar epithelium at the junction of hyperplasia, the number increased, and along the horizontal direction to the uterine cavity, while infiltration of cervical deep stroma and myometrium. Adenoma epithelial cells arranged in a monolayer, similar to the normal cervical canal gland, but the visible part of the irregular shape of the nucleus and the size of the gland, careful observation will be able to see mitosis. The prognosis of patients is closely related to the clinical stage of the tumor. Mucin histochemistry and CEA immunohistochemical staining contribute to the differential diagnosis.