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目的了解艾滋病病毒Ⅰ型(HIV-1)在肝组织的表达和分布情况,探讨HIV/艾滋病(AIDS)病人发生肝损害的可能机制。方法先后采用免疫组织化学方法和核酸原位杂交方法,检测HIV/AIDS病人肝组织病理切片中的HIV-p24抗原和HIV-1核酸。结果14例HIV/AIDS病人肝切片组织的Kupffer细胞、淋巴细胞、血管内皮细胞和肝细胞,均检测到HIV-p24抗原。所有切片组织的Kupffer细胞、淋巴细胞有HIV RNA阳性表达,其中4例标本的肝细胞浆内有HIV RNA表达。结论HIV-1可能在肝脏实质细胞和间质细胞内复制表达,并引起肝脏损害。
Objective To understand the expression and distribution of HIV-1 in liver and explore the possible mechanism of liver damage in HIV / AIDS patients. Methods Immunohistochemistry and nucleic acid in situ hybridization were used to detect HIV-p24 antigen and HIV-1 nucleic acid in liver biopsy specimens of HIV / AIDS patients. Results HIV-p24 antigen was detected in Kupffer cells, lymphocytes, vascular endothelial cells and hepatocytes in 14 sections of HIV / AIDS patients. In all the sections, Kupffer cells and lymphocytes were positive for HIV RNA, of which HIV RNA was expressed in the cytoplasm of liver cells in 4 specimens. Conclusion HIV-1 may be expressed in liver parenchymal cells and interstitial cells and cause liver damage.