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目的评估胰岛素样生长因子Ⅰ（ＩＧＦⅠ）在胎儿、胎盘生长发育中的作用。方法用放射免疫分析法（ＲＩＡ）测定大于胎龄儿（ＬＧＡ）组３０例，适于胎龄儿（ＡＧＡ）组３６例及小于胎龄儿（ＳＧＡ）组３６例的脐血清ＩＧＦⅠ的水平。用线性相关分析法分析各组变量之间的相关关系。结果３组胎儿脐血清ＩＧＦⅠ与胎龄、胎儿体重、胎盘重量均呈显著正相关（ｒ＝０．３２，Ｐ＜０．００１；ｒ＝０．６８，Ｐ＜０．００１；ｒ＝０．７５，Ｐ＜０．０１），其中与胎盘重量呈高度正相关。脐血清ＩＧＦⅠ水平，ＡＧＡ组为１４４５９±４６．７３μｇ／Ｌ；ＳＧＡ组为９０．８０μｇ／Ｌ（ｔ＝４．７，Ｐ＜０．００１），ＬＧＡ组为２０９１７μｇ／Ｌ（ｔ＝７．９７，Ｐ＜０．００１）。结论ＩＧＦⅠ是胎儿、胎盘生长发育的重要调节因子，对巨大儿、小于胎龄儿的形成有重要作用。
Objective To evaluate the role of insulin-like growth factor-Ⅰ (Ⅰ-Ⅰ) in fetal and placental growth and development. Methods Radioimmunoassay (RIA) was used to determine the levels of IGF-Ⅰ in 30 cases of LGA group, 36 cases of AGA group and 36 cases of SGA group Level. Linear correlation analysis was used to analyze the correlation between each group of variables. Results There was a significant positive correlation between IGFⅠ in fetal umbilical cord serum and gestational age, fetal weight and placenta weight (r = 0.32, P <0.001; r = 0.68, P <0.001) 0.75, P <0.01), which was positively correlated with the weight of placenta. Cord blood serum IGF Ⅰ level, AGA group was 14459 ± 46.73μg / L; SGA group was 90.80μg / L (t = 4.7, P <0.001), LGA group was 20917μg / L (T = 7.97, P <0.001). Conclusion IGF Ⅰ is an important regulator of fetal and placental growth and development, and plays an important role in the formation of giant and small gestational age children.