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目的探讨非酒精性脂肪肝(NAFLD)与糖脂代谢异常的关系。方法以3647名NAFLD患者与同时参加体检的6338名非脂肪肝健康体检者(对照组)的糖脂代谢相关指标进行统计分析。结果9985名企业退休人员体检检出NAFLD3647名,患病率为36·5%。NAFLD组的体重、体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、胆固醇(TC)、甘油三酯(TG)、谷丙转氨酶(ALT)、空腹血糖(FBS)均高于对照组,差异有统计学意义。NAFLD组中高甘油三酯血症、高胆固醇血症、混合性高脂血症、超重、肥胖、空腹血糖受损、糖尿病的患病率均高于对照组。将NAFLD的可能危险因素进行logistic回归分析,相关性由高到低依次为:BMI(OR=I·785,P=0·000)、TG(0R=1·712,P=0·000)、FBS(0R=1·157,P=0·000)、TC(0R=1·138,P=0·005)、身高(0R=1·105,P=0·005)、ALT(OR:1·013,P=0·000)、DBP(0R=1·008,P=0·031)与NAFLD相关,而促甲状腺素(TSH)未能进入模型(P=0·631)。结论企业退休人员NAFLD的患病率高,NAFLD与糖脂代谢的多项指标相关,而TSH与NAFLD无显著相关。
Objective To investigate the relationship between nonalcoholic fatty liver disease (NAFLD) and abnormal glucose and lipid metabolism. Methods A total of 3647 NAFLD patients and 6338 non-fatty liver healthy subjects (control group) who participated in the physical examination at the same time were analyzed for glucose and lipid metabolism. Results Nine thousand nine hundred and seventy five retirees were examined by NAFLD 3647, the prevalence was 36.5%. Body weight, body mass index (BMI), SBP, DBP, TC, TG, ALT and FBS in NAFLD group were significantly higher than those in NAFLD group The control group, the difference was statistically significant. In NAFLD group, the prevalence of hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia, overweight, obesity, impaired fasting glucose and diabetes was higher than that of the control group. Logistic regression analysis of the possible risk factors for NAFLD showed that the correlations were higher in the order of BMI (OR = 1.785, P = 0.000), TG (0R = 1.1212, P = 0.000) FBS (0R = 1 · 157, P = 0.000), TC (0R = 1 · 138, P = 0 · 005) (P = 0.006). However, DBP (0R = 1 · 008, P = 0 · 031) was associated with NAFLD, while thyrotropin (TSH) failed to enter the model (P = 0.631). Conclusion The prevalence of NAFLD is high in retired workers. NAFLD is associated with a number of indicators of glucose and lipid metabolism, while there is no significant correlation between TSH and NAFLD.