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片剂或胶囊剂如果不用充足的水服用,往往会延长在食管内的通过时间。尤其以躺卧姿势服药,或刚服药之后即又躺卧时,可以想象这种现象会更为显著。如果药物在食管通过时间长,一方面,由药物引起的消化道溃疡会增多;另一方面,有时药物通过消化道吸收减慢而使药效降低。日本学者用扑热息痛片进行片剂在食管通过时间与主药吸收等方面的试验,20名住院患者参加了这项试验。试验用药物系每片含有扑
Tablets or capsules often take longer to pass through the esophagus if taken without adequate water. Especially when taking medicine in a lying position or when lying down again just after taking the medicine, this phenomenon can be imagined even more conspicuously. If the drug in the esophagus through a long time, on the one hand, caused by the drug peptic ulcer will increase; the other hand, sometimes drugs through the digestive tract to slow down and reduce the efficacy. Japanese scholars used paracetamol tablets tablets in the esophageal passage of time and the main drug absorption tests, 20 in-patients participated in the trial. The experimental drug contains a flutter per tablet