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目的分析我院川崎病(Kawasaki Disease,KD)住院患儿445例临床特征,探讨其冠状动脉损害(coronary artery lesions,CALs)的发生、转归与高危因素。方法对2006-2010年在我院确诊为KD的住院患儿的临床资料、冠状动脉病变及预后作回顾性分析。结果共445例KD患儿,川崎病占75.28%,不完全川崎病24.72%。心脏损害发生率为21.46%,CALs发生率为18.72%。丙球无反应型占2.82%,复发率为1.57%。经过1-5年的随访:有55例(67.07%)恢复正常,其中15例(27.27%)1周内恢复正常,25例(45.45%)1个月内恢复,11例(20.00%)半年内恢复,4例(7.27%)1年内恢复正常。单因素分析显示丙球无反应型,血红蛋白(Hb)、血清白蛋白(ALB)的下降及血沉(ESR)的上升与CALs具有相关性(P<0.05)。结论近似反映了苏州地区KD发病情及冠状动脉病变与转归,CALs高危因素研究显示与丙球无反应型、贫血、低白蛋白血症及ESR的上升具有相关性。
Objective To analyze the clinical characteristics of 445 hospitalized children with Kawasaki Disease (KD) in our hospital and investigate the occurrence, prognosis and risk factors of coronary artery lesions (CALs). Methods The clinical data, coronary artery lesions and prognosis of hospitalized children diagnosed as KD in our hospital from 2006 to 2010 were analyzed retrospectively. Results A total of 445 children with KD, Kawasaki disease accounted for 75.28%, incomplete Kawasaki disease 24.72%. The incidence of heart damage was 21.46% and the incidence of CALs was 18.72%. B ball non-reactive accounted for 2.82%, the recurrence rate was 1.57%. After 1 to 5 years of follow-up, 55 cases (67.07%) returned to normal, of which 15 (27.27%) returned to normal within 1 week, 25 (45.45%) recovered within 1 month and 11 (20.00% Within 4 years (7.77%) recovered within 1 year. Univariate analysis showed that there was a correlation between non-responsive type of C-reactive protein, decrease of hemoglobin (Hb), serum albumin (ALB) and rise of erythrocyte sedimentation rate (ESR) with CALs (P <0.05). Conclusion The KD incidence and coronary artery disease in the Suzhou area are similar to those in the control group. The study of the risk factors of CALs showed no correlation with anemia, anemia, hypoalbuminemia and ESR.