论文部分内容阅读
目的探讨非霍奇金淋巴瘤患者血管内皮生长因子(VEGF)表达与预后的关系。方法选择62例非霍奇金淋巴瘤患者为观察组,选择同期门诊体检的50例健康者为对照组,比较两组VEGF和微血管密度(MVD)的差别及其与观察组患者预后的关系。结果观察组患者VEGF和MVD水平均显著高于对照组,差异有统计学意义(P=0.000);观察组患者VEGF阳性者3年生存率(41.9%)显著低于VEGF阴性者(89.5%),差异有统计学意义(P=0.001);观察组Ⅲ、Ⅳ期患者的VEGF和MVD水平显著高于Ⅰ、Ⅱ期患者,差异有统计学意义(P=0.000);侵袭性患者的VEGF和MVD水平显著高于惰性者,差异有统计学意义(P=0.000);随着国际预后指数(IPI)危险级别的升高,患者的VEGF和MVD水平逐渐升高,差异有统计学意义(P=0.000);化疗疗效稳定和进展患者的VEGF和MVD水平显著高于完全缓解和部分缓解患者,差异有统计学意义(P=0.000)。结论非霍奇金淋巴瘤患者的VEGF高表达与临床分期和病理分型相关,且对化疗疗效有一定预测价值。
Objective To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and prognosis in non-Hodgkin’s lymphoma. Methods Sixty-two patients with non-Hodgkin’s lymphoma were selected as the observation group. Fifty healthy subjects selected during the same period as the control group were selected as the control group. The difference between the two groups was compared with the prognosis of the patients in the observation group. Results The levels of VEGF and MVD in the observation group were significantly higher than those in the control group (P = 0.000). The 3-year survival rate (41.9%) in the VEGF-positive group was significantly lower than that in the VEGF-negative group (89.5% (P = 0.001). The levels of VEGF and MVD in patients in stage Ⅲ and stage Ⅳ were significantly higher than those in stage Ⅰ and Ⅱ (P = 0.000), while the levels of VEGF and MVD in patients with stage Ⅲ and Ⅳ were significantly higher than those in stage Ⅰ and Ⅱ (P = 0.000). The level of VEGF and MVD increased with the increase of the international prognosis index (IPI) risk level, the difference was statistically significant (P = 0.000). The levels of VEGF and MVD in patients with stable and advanced chemotherapy were significantly higher than those in patients with complete remission and partial remission, the difference was statistically significant (P = 0.000). Conclusion The high expression of VEGF in non-Hodgkin’s lymphoma is correlated with clinical stage and pathological classification, and has certain predictive value for the curative effect of chemotherapy.