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目的:观察口服中药、足部贴敷联合常规治疗方案治疗顽固性口腔溃疡的疗效,并研究其作用机制。方法:纳入80例顽固性口腔溃疡患者,随机均分为2组,对照组仅予常规治疗,观察组在对照组治疗基础上行中药内服、足部贴敷,持续治疗4周,对比用药5天后的疗效、主要症状缓解时间、治疗前后T淋巴细胞亚群及血清炎性因子水平。结果:治疗5天,观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组红肿及疼痛消失时间、溃疡面愈合时间均短于对照组,差异均有统计学意义(P<0.01)。治疗后,观察组CD3~+、CD4~+/CD8~+、IL-2水平均高于对照组(P<0.05,P<0.01),TNF-α水平低于对照组(P<0.01)。结论:口服中药、足部贴敷联合常规治疗方案的中西医结合疗法有助于提升顽固性口腔溃疡的疗效,其机制可能与更好地改善免疫失衡、调控炎性反应有关。
Objective: To observe the curative effect of oral traditional Chinese medicine and foot sticking combined with routine treatment on refractory oral ulcer and to study its mechanism. Methods: Eighty patients with stubborn mouth ulcers were enrolled and randomly divided into two groups. The control group was treated only routinely. The observation group was given oral administration of Chinese medicine and foot for 4 weeks on the basis of the control group. After 5 days of treatment, Efficacy, the main symptoms of remission, T lymphocyte subsets and serum levels of inflammatory cytokines before and after treatment. Results: After 5 days of treatment, the total effective rate of observation group was higher than that of control group, the difference was statistically significant (P <0.05). The swelling and the disappearance time of pain and healing time of ulcer in the observation group were shorter than those in the control group, with statistical significance (P <0.01). After treatment, the levels of CD3 ~ +, CD4 ~ + / CD8 ~ + and IL-2 in the observation group were higher than those in the control group (P <0.05, P <0.01), while the levels of TNF-α in the observation group were lower than those in the control group (P <0.01). Conclusion: The combination of traditional Chinese medicine and western medicine combining traditional Chinese medicine and foot sticking with routine treatment can improve the curative effect of intractable oral ulcer. The mechanism may be related to improving immune imbalance and regulating inflammatory reaction.