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目的了解安徽省既往有偿供血艾滋病病毒(HIV)感染者合并弓形虫感染状况,及其对艾滋病疾病进展的影响。方法以招募的安徽省既往有偿供血员HIV阳性感染者为研究对象,采集外周血,分离血浆,通过酶联免疫吸附试验(ELISA)检测弓形虫抗体。同时检测CD4T细胞和血浆病毒载量的水平。结果在招募的367例中,合并弓形虫感染者11例,感染率为3.0%,主要存在于CD4+T细胞数量低于200/mm3的感染者中。合并弓形虫感染者的CD4+T细胞数低于HIV单一感染者,而病毒载量则呈相反趋势。结论对晚期HIV感染者的管理,在监测CD4+T细胞的同时,应加强监测弓形虫的混合感染,以把握预防用药的合理时机,降低混合感染造成的死亡。
Objective To understand the prevalence of Toxoplasma gondii infection in Anhui Province in the past with HIV-infected patients and its impact on the progression of AIDS. Methods The HIV-positive patients who were recruited from Anhui Province were enrolled in this study. Peripheral blood was collected and plasma was separated. Toxoplasma gondii antibodies were detected by enzyme linked immunosorbent assay (ELISA). Simultaneous detection of CD4 T cell and plasma viral load levels. Results Among the 367 recruited patients, 11 were infected with Toxoplasma gondii and the infection rate was 3.0%. The infection rate was mainly found in those with CD4 + T cell count less than 200 / mm3. Toxoplasma gondii infection with CD4 + T cell number lower than HIV single infection, while the viral load was the opposite trend. Conclusions In the management of patients with advanced HIV infection, we should monitor the mixed infection of Toxoplasma gondii while monitoring CD4 + T cells so that we can take reasonable time to prevent medication and reduce the death caused by mixed infection.