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不同类型的哮喘儿童不仅对药物的应答不同,还表现出不同的病程,美国波士顿的Dr.Benjamin A.Raby及其同事发表在Journal of Allergy and Clinical Immunology杂志如是说。研究者以疾病表型为基础,对超过1 000例哮喘儿童进行了聚类分析,以明确不同类型的患儿对药物治疗的应答是否有差异。这些受试患儿均来自于为期48个月的CAMP试验。对18个基线表型特征进行频谱分析后,儿童哮喘被分为5个不同的表型。人数最多的
Different types of asthma children not only respond to different drugs, but also show a different course of disease, Dr. Benjamin A. Raby, Boston, USA and colleagues published in the Journal of Allergy and Clinical Immunology magazine said. Based on the disease phenotype, the researchers conducted a cluster analysis of more than 1,000 asthmatic children to determine whether different types of children respond differently to medications. The subjects were all from the CAMP trial for 48 months. After 18 baseline phenotypic characteristics were analyzed by frequency spectrum, childhood asthma was divided into 5 different phenotypes. The largest number