吲哚胺2,3双加氧酶(indoleam ine2,3-d ioxygenase,IDO)是必需氨基酸色氨酸分解代谢的胞内限速酶,在肿瘤介导的免疫抑制方面引起了诸多关注。IDO表达与多种恶性肿瘤的不良预后相关,如子宫内膜癌、卵巢癌、宫颈癌、白血病和大肠癌。了解IDO的作用机制及反作用原理,为妇科肿瘤的临床治疗提供新的思路,具有积极的实用价值与临床意义。 Indoleamine 2, 3 dioxygenase (IDO) is an intracellular rate-limiting enzyme that is responsible for the tryptophan catabolism of essential amino acids, attracting much attention in terms of tumor-mediated immunosuppression. IDO expression is associated with poor prognosis for a variety of malignancies, such as endometrial cancer, ovarian cancer, cervical cancer, leukemia, and colorectal cancer. Understand the mechanism of action and counteraction of IDO, provide new ideas for the clinical treatment of gynecologic oncology, have positive practical value and clinical significance.