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目的通过收集在广西生殖健康中心行体外受精-胚胎移植(IVF-ET)不孕症妇女子宫内膜和息肉组织做病理切片苏木素-伊红(HE)染色和孕激素受体(PR)免疫组化染色，观察PR表达分布情况，为研究提高子宫内膜息肉(EP)不孕症患者妊娠率提供参考依据。方法在广西生殖健康中心收集30例确诊为EP不孕症并行IVF-ET患者的子宫内膜和息肉组织作研究组，另取30例同期在本中心以丈夫不育为主因行IVF-ET的非EP患者(接近正常)子宫内膜组织作正常对照组，同期再在广西医科大学一附院计生门诊收集30例非EP、非不孕症的放取环诊刮患者子宫内膜组织作非IVF-ET对照组，分别进行病理切片HE染色及PR免疫组化染色。结果免疫组化染色显示，正常对照组腺上皮和间质细胞胞浆和胞核均未有明显阳性表达；放取环非IVF-ET组可见腺上皮和间质细胞普遍阳性表达，腺上皮的胞浆、胞核均有表达，间质细胞部分胞核表达；研究组内膜组织主要为腺上皮胞核强阳性表达，腺腔内分泌物及间质细胞也有一定阳性表达；研究组息肉组织主要为局部腺上皮胞浆强阳性表达，胞核少表达，间质细胞轻度阳性表达。结论广西IVE-ET的EP不孕患者子宫内膜组织PR在腺上皮胞核强阳性表达而间质细胞有一定表达，息肉组织局部腺上皮胞浆强阳性表达，胞核少表达，间质细胞轻度阳性表达。“,”Objective To observe the expression and distribution of Progestrone Receptors(PR) Immunohistochemical staining in endometrium and Endometrial Polyp(EP) tissues who performed In Vitro Fertilization-Embryo Transfer(IVF-ET) in Guangxi Reproductive Health Center (GXRHC), so that to provide the reference for researching how to improve pregnancy rate in EP patients with infertility. Methods Col ected 30 patients who were diagnosed with EP infertility and planned perform IVF-ET in GXRHC as a research group;meanwhile, the other similar 30 cases were male factor (husband infertility) but nor EP (close to the normal) as a normal control group, 30 cases were col ected in the family planning outpatients of First Af iliated Hospital of Guangxi Medical University who were put in or taken out an intrauterine device (IUD) as a nor IVF-ET control group. Al the endometrium and/or endometrial polyps tissues were obtained by hysteroscopic polypectomy or curet age, and were done HE staining and PR immunohistochemical staining, and then observed the expression of PR. Results Compared with the control group, nuclei of glandular cel s showed higher positive expression,lumens secretions and interstitial cel had a certain positive expression in research group endometrium; but in endometrial polyps, local region cytoplasm of glandular cel s showed strong positive expression, the nuclei of glandular cel s seldom expression, and the interstitial cel to showed a lit le bit expressed. Conclusion Nuclei of glandular cel s showed higher positive expression in endometrium but part region cytoplasm of glandular cel s showed strong positive expression in endometrial polyps of EP infertility women who performed IVE-ET in Guangxi.