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目的探讨1,6-二磷酸果糖联合维生素C对新生儿窒息后心肌损害的治疗作用。方法新生儿窒息合并心肌损害患儿共36例,随机分为治疗组和对照组各18例。两组均给予吸氧,丹参注射液,能量合剂静脉点滴,每日一次,7天一疗程,治疗组加用1,6-二磷酸果糖(150mg/kg/d)和维生素C(200mg/kg/d)静脉点滴,5天为一疗程。观察治疗前后血清肌钙蛋白-I(cTnI)和肌酸激酶同工酶(CK-MB)含量的变化。结果两组治疗前血清cTnI和CK-MB水平比较差异无统计学意义,治疗后两组血清cTnI和CK-MB均较治疗前下降,治疗后血清cTnI治疗组下降程度明显大于对照组(t=3.52,P<0.01);治疗后CK-MB治疗组与对照组比较无明显差异(t=1,P>0.05)。结论1,6-二磷酸果糖联合维生素C对新生儿窒息后心肌损伤有较好的治疗作用,能改善预后。
Objective To investigate the therapeutic effect of fructose-1,6-diphosphate combined with vitamin C on myocardial damage after neonatal asphyxia. Methods A total of 36 children with neonatal asphyxia and myocardial damage were randomly divided into treatment group and control group, 18 cases each. The two groups were given oxygen, Salvia injection, energy mixture intravenous drip once a day for 7 days a course of treatment, the treatment group with fructose 1,6-diphosphate (150mg / kg / d) and vitamin C (200mg / kg / d) intravenous drip, 5 days for a course of treatment. The changes of serum cTnI and CK-MB before and after treatment were observed. Results There was no significant difference in serum cTnI and CK-MB levels between the two groups before treatment. Serum levels of cTnI and CK-MB decreased after treatment in both groups. The decrease in serum cTnI after treatment was significantly greater than that in the control group (t = 3.52, P <0.01). There was no significant difference between the CK-MB treatment group and the control group after treatment (t = 1, P> 0.05). Conclusion Fructose-1,6-diphosphate combined with vitamin C has a good therapeutic effect on neonatal asphyxia myocardial injury, which can improve the prognosis.