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目的 :探讨大容量肺泡灌洗对肺泡蛋白沉积症患者的生活质量及肺功能的影响。方法 :对11例肺泡蛋白沉积症患者进行大容量肺泡灌洗并长期随访,比较灌洗前后患者呼吸困难严重程度分级(medical research council dyspnoea scale,MRC)、SF-36v2评分、动脉血氧分压(Pa O2)、肺泡动脉氧分压差[D(A-a)O2]及肺功能指标。结果 :经大容量肺泡灌洗后患者的SF-36v2评分、动脉血气分析、肺弥散功能及影像学表现有不同程度的改善。结论:大容量肺泡灌洗能够改善患者症状,提高患者生活质量,延长患者生命,改善动脉血氧分压、肺弥散功能及影像学表现,降低肺泡动脉氧分压差。
Objective: To investigate the effect of high-volume alveolar lavage on the quality of life and pulmonary function in patients with pulmonary alveolar proteinosis. Methods: Eleven patients with pulmonary alveolar proteinosis were treated with large volume alveolar lavage and long-term follow-up. Before and after lavage, the patients were divided into two groups: medical research council dyspnoea scale (MRC), SF-36v2 score, arterial oxygen pressure (Pa O2), alveolar arterial oxygen pressure difference [D (Aa) O2] and lung function index. Results: SF-36v2 score, arterial blood gas analysis, diffuse lung function and imaging findings of the patients after the large-volume alveolar lavage were improved to some extent. Conclusion: Large volume alveolar lavage can improve symptoms, improve patient quality of life, prolong patient life, improve arterial partial pressure of oxygen, diffuse pulmonary function and imaging findings and reduce the differential pressure of alveolar arterial oxygen.