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目的:探讨肾小球样结构在前列腺癌病理切片中的形态学特征、发生率、与临床特征的联系以及对预后判断的意义。方法:收集华中科技大学同济医学院附属同济医院196例前列腺癌患者的临床资料、病理诊断、Glea-son评分以及TNM分期等,对病理报告伴有肾小球样结构的病例分析其组织学特征,结合文献分析肾小球样结构对前列腺癌诊断、预后的意义。结果:196例前列腺癌标本中3例出现肾小球样结构,其中2例伴有周围神经侵犯,1例伴有骨转移;Gleason评分分别为7分、8分和8分;随访5～15个月,1例已死亡,1例在接受内分泌治疗,1例行前列腺癌根治术后处于随访中。结论:肾小球样结构是一种少见的前列腺癌病理特征,其形态学特征鲜明,对前列腺恶性病变具有诊断价值并提示较差的预后。
OBJECTIVE: To investigate the morphological characteristics, incidence, clinical features and the significance of glomerular-like structure in the pathological diagnosis of prostate cancer. Methods: The clinical data, pathological diagnosis, Glea-son score and TNM staging of 196 cases of prostate cancer in Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology were collected. The histological features of glioma-like structures in pathological reports were analyzed , Combined with the literature analysis of glomerular-like structure of prostate cancer diagnosis, prognostic significance. Results: Glomerular structures were observed in 3 of the 196 specimens of prostate cancer, including 2 with peripheral nerve invasion and 1 with bone metastasis. The Gleason score was 7, 8 and 8, respectively. The follow-up ranged from 5 to 15 One month, one patient died, one was undergoing endocrine therapy and one was undergoing follow-up after radical prostatectomy. Conclusion: The glomerular-like structure is a rare pathological feature of prostate cancer. Its morphological characteristics are distinct and have diagnostic value for malignant prostatic lesions and suggest a poor prognosis.