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目的了解北海市妊娠中晚期孕妇人群的碘营养状况,探讨尿碘筛查的时机和科学指导碘摄入的理论依据。方法利用碘催化砷铈反应原理,采用冷消解快速尿碘定量检测方法测定613例孕妇(其中孕中期195例,孕晚期418例)随意尿的碘含量。结果 613例孕妇尿碘中位数是206μg/L,其中尿碘≤100μg/L者占17.78%,尿碘<50μg/L者占4.73%。而孕中、晚期孕妇尿碘中位数分别是149、295μg/L,其中尿碘<150μg/L者所占比例分别为50.26%、26.32%,尿碘≤100μg/L者所占比例分别为24.10%、14.84%,尿碘<50μg/L者所占比例分别为6.15%、4.07%。孕中期尿碘水平低于孕晚期(Z=-8.420,P<0.01),低尿碘率高于孕晚期(χ2=34.00,P<0.01)。高尿碘组孕晚期的尿碘水平高于孕中期(χ2=6.140,P<0.05),低尿碘组和正常尿碘组孕中、晚期的尿碘水平差异无显著性(χ2=0.930~2.097,P>0.05)。结论孕中期前是尿碘筛查、及时纠正碘营养状况的最佳时机,应根据尿碘水平变化评估孕晚期孕妇个体碘的需求,合理调整碘营养。
Objective To understand the status of iodine nutrition in pregnant women in the second and third trimester of pregnancy in Beihai and to explore the timing of urinary iodine screening and the theoretical basis for the scientific guidance of iodine intake. Methods The urinary iodine content of 613 pregnant women (195 in the second trimester and 418 in the third trimester of pregnancy) was determined by iodine-catalyzed arsenic-cerium reaction. Results The median urinary iodine of 613 pregnant women was 206 μg / L, with urinary iodine ≤ 100 μg / L accounting for 17.78% and urinary iodine <50 μg / L accounting for 4.73%. The median urinary iodine of pregnant women and late pregnant women were 149,295μg / L, respectively, of which the urinary iodine <150μg / L accounted for 50.26%, 26.32%, urinary iodine ≤100μg / L respectively 24.10%, 14.84%, urinary iodine <50μg / L, respectively, the proportion of 6.15%, 4.07%. The urinary iodine level in the second trimester was lower than that in the second trimester (Z = -8.420, P <0.01), and the low urinary iodine rate was higher than that in the third trimester (χ2 = 34.00, P <0.01). The level of urinary iodine in the third trimester was higher than that in the third trimester (χ2 = 6.140, P <0.05) in the high-urinary iodine group. There was no significant difference in urine iodine level between the low-urinary iodine group and the normal urinary iodine group (χ2 = 0.930 ~ 2.097, P> 0.05). Conclusion Before the second trimester of urine iodine screening, timely correction of iodine nutritional status of the best time, should be based on changes in urinary iodine levels in pregnant women to assess the individual needs of pregnant women, rational adjustment of iodine nutrition.